Control and Activity of the Streptomyces Spore Wall Synthesizing Complex (SSSC) (A02)

在抗生素产生链霉菌的生命周期中，菌丝以高度同步的方式分离成50多个孢子的链。链霉菌孢子壁合成复合物SSSC类似于杆状细菌的延长酶体，在此过程中起关键作用。我们希望阐明链霉菌孢子壁合成复合物SSSC如何实现肽聚糖和阴离子糖共聚物的合成以及蛋白质磷酸化如何控制SSSC的配位。

During the life cycle of antibiotic producing streptomycetes the hyphae are septated into chains of more than 50 spores in a highly synchronized manner. The Streptomyces spore wall synthesizing complex SSSC, which resembles the elongasome of rod-shaped bacteria has a key role in this process. We want to elucidate how the Streptomyces spore wall synthesizing complex SSSC achieves the synthesis of peptidoglycan and anionic glycopolymers and how protein phosphorylation controls the coordination of the SSSCs.