Role of sex hormones on microbiome, immunity, and coronary microvascular dysfunction and rarefication in experimental HFpEF (A05)

HFpEF更常在女性中诊断，尤其是绝经后，但平均而言，她们面临的有效护理较少。我们假设HFpEF中的性别差异反映了1）性类固醇直接或间接对肠道微生物组、循环代谢物或免疫系统的影响;反过来通过2）冠状动脉微血管功能障碍起作用。将多组学技术应用于内分泌性别可以操纵的HFpEF动物模型，我们将测试这一假设并确定其特定的微生物，免疫和分子驱动因素。通过对来自该CRC和其他来源的宿主微生物组数据进行综合和比较分析，将结果投射到人类环境中。

HFpEF is more often diagnosed in women, especially post menopause, but who on average face less effective care. We hypothesize sex differentially in HFpEF reflect 1) sex steroid impact directly or indirectly on gut microbiome, circulating metabolites, or immune system; in turn acting through 2) coronary microvascular dysfunction. Applying multi-omics technologies to animal models of HFpEF where endocrine sex can be manipulated, we will test this hypothesis and determine its specific microbial, immune and molecular drivers. Findings will be projected into the human setting by integrative and comparative analysis of host-microbiome data from this CRC and other sources.