Total Synthesis of Complex Natural Products

本课题组开展了复杂天然产物的全合成研究。本研究以紫杉烷类二萜为主要合成目标，采用AC片段的B环化方法，实现了（+）-紫杉醇和（-）-紫杉醇的对映选择性全合成，并合成了根赤壳醇、pironectin、tanabalin、furaquinocine和polycervernoside等具有代表性的天然产物。还开发了zoanthamine/nor-zoanthamine生物碱和ravidomycin。

Total syntheses of complex natural products have been studied in this research group. During this investigation, taxane diterpene was one of major synthetic targets, and enantioselective total syntheses of (+)-taxusin and (-)-taxol have been efficiently achieved based on the B ring cyclization methodology of AC fragment.Other representative natural products synthesized during this research period are radicicol, pironectin, tanabalin, furaquinocine, and polycavernoside.Synthtic studies on α,α-disubstituted α-amino acid sub-structure, zoanthamine/nor-zoanthamine alkaloids, and ravidomycin were also developed.