Lymphangiogenesis in cancer

寻找抑制肿瘤转移的方法对肿瘤的治疗具有重要意义。我们发现了转移的两个重要机制：1）淋巴管生成的作用，2）从非癌干细胞诱导癌干细胞。淋巴管生成促进转移。我们成功地通过抗淋巴管生成治疗抑制转移的小鼠模型。然而，我们发现癌症干细胞不具有淋巴管生成的潜力。为了抑制转移，靶向诱导转移部位的癌症干细胞可能是重要的。

To find the way of the inhibition of metastasis is important for cancer therapy. We found 2 important mechanisms in metastasis; 1) the role of lymphagiogenesis, 2) the induction of cancer stem cells from non-cancer stem cells. Lymphangiogenesis promotes the metastasis. We succeeded the inhibition of metastasis by anti-lymphangiogenesis therapy in mouse model. However, we found that cancer stem cells don't have the potential of lymphangiogenesis. To inhibit the metastasis, it could be important to target the induction of cancer stem cells in the metastatic sites.