Microglial lipid metabolism during physiological and pathological conditions

小胶质细胞的一个重要任务是吞噬和分解死细胞和细胞外沉积的蛋白质和脂质。在病理条件和衰老过程中，细胞外沉积物的存在会增加。由于大量不同的中枢神经系统细胞类型，它们反过来又表达特定的蛋白质库，小胶质细胞必须能够适应它们的代谢和分解代谢，以避免细胞内脂质积累，从而导致小胶质细胞的激活。例如，在阿尔茨海默病等神经退行性疾病中，激活的小胶质细胞会导致临床病程的恶化。在本研究项目中，我们想研究是否以及如何利用小胶质细胞的脂质代谢来增加脂质分解代谢，从而减少小胶质细胞的活化。研究结果可以帮助确定新的治疗干预方案，例如用于阿尔茨海默病。

An important task of microglia is the phagocytosis and the breakdown of dead cells and extracellularly deposited proteins and lipids. The presence of extracellular deposits can increase under pathological conditions and aging processes. Due to the large number of different CNS cell types, which in turn all express a specific repertoire of proteins, microglia must be able to adapt their metabolism and catabolism to the phagocytosed material in order to avoid an intracellular accumulation of lipids, which in turn leads to the activation of microglia. This is the case, for example, during neurodegenerative diseases such as Alzheimer's disease, where activated microglia can contribute to a worsening of the clinical disease course.In this research project we want to investigate whether and how the lipid metabolism in microglia can be used to increase lipid catabolism and thereby reduce the activation of microglia. The results can help to identify new therapeutic intervention options that can be used, for example, in Alzheimer's disease.