Structural analyses of the interaction between extracellular ligands and their receptors

我们利用X射线结晶学和电子显微镜来破译细胞受体识别细胞外环境线索的结构机制。我们已经获得了有关脑发育中的reelin信号转导以及与癌症和骨形成有关的Wnt信号转导的信息。此外，我们还解开了神经元突触黏附机制的结构，并成功地在原位感染过程中可视化了水稻矮缩病毒。

We have utilized X-ray crystallography and electron microscopy to decipher the structural mechanism underlying recognition of extracellular environmental cues by cellular receptors. We have gained information about reelin signal transduction in brain development and Wnt signal transduction implicated in cancer and bone formation. Also, we have unraveled the structure of neuronal synapse adhesion machinery, and succeeded in visualizing the rice dwarf virus during the infection in situ.