3Tesla magnet resonance tomograph

鲁尔波鸿大学进行的神经科学和认知研究的一个重点是研究健康和功能障碍大脑中信息处理和认知的机制。在过去的十年中，我们已经开发了功能性磁共振成像（fMRI）的专业知识，使我们能够从事高分辨率的功能分化的大脑区域和神经表征，从事记忆的形成，或畸形，并在审查的变化，发生在中枢神经系统疾病的进展。我们的方法包括联合EEG/fMRI，神经突方向和弥散成像（NODDI），神经递质光谱和扩散张量成像（DTI）。这项研究是我们目前和计划中的合作研究联盟的核心，这些联盟专注于学习和记忆的不同方面，以及脑部疾病。因此，最先进的3，0 MRI设备的可用性不仅对上述研究至关重要，而且应作为进一步研究创新和新举措的中心。该设备应满足技术规范，允许在基础研究水平上检查空间导航的神经表征，并审查树突密度在认知灵活性（NODDI）中的作用。例如，在临床和翻译水平上，我们的目标是使用组合的EEG/fMRI来检查顶叶和运动皮层之间的通信，以及神经反馈学习期间海马和顶叶皮层之间的通信，目的是开发策略来优化截瘫患者由皮层刺激（以及随后的皮层适应）驱动的到达和保持运动。此外，我们计划使用fMRI，DTI和光谱学来检查感觉信息传递的基础过程，以及检查多发性硬化症（MS）进展过程中的炎症和神经退行性变过程。还应使用DTI、fMRI和静息状态MRI（rsMRI）检查疼痛、压力和人格或情感障碍的情绪和认知表现，以及治疗期间这些推定生物标志物的推定变化。收购最先进的3，0 MRI设备以取代我们12年的现有设备将大大加强我们目前的研究，并使我们能够充分利用我们在先进MRI方法学方面的专业知识。通过这种方式，我们打算为我们对支持记忆获取和更新的大脑系统和神经亚区室的理解做出新的贡献，以及在失调或疾病状态下的认知处理。通过在适应过程中观察大脑（神经反馈学习，对疼痛/压力/情感障碍的认知适应，大脑对治疗性治疗的反应），我们希望使用这种方法来加速大脑恢复和/或抵抗病理状态。

A key focus of the neuroscientific and cognitive research conducted by the Ruhr University Bochum comprises the study of mechanisms underlying information processing and cognition in the healthy and dysfunctional brain. Over the last decade we have developed functional magnetic resonance imaging (fMRI) expertise that allows us to engage in high-resolution functional differentiation of brain regions and neural representations that engage in memory formation, or malformation, and in the scrutiny of changes that occur in the CNS during disease progression. Our methodology includes combined EEG/fMRI, neurite orientation and dispersion imaging (NODDI), neurotransmitter spectroscopy and diffusion tensor imaging (DTI). This research is at the heart of our current and planned collaborative research consortia that focus on different aspects of learning and memory, as well as on brain disease. Thus, the availability of a state-of-the art- 3,0 MRI device is not only essential for the abovementioned research, but shall serve as a hub for further research innovation and new initiatives.The device should fulfill technical specifications to permit, at the level of basic research, examination of neural representations of spatial navigation and the scrutiny of the role of dendrite density in cognitive flexibility (NODDI). At the clinical and translational levels our goal, for example, is to use combined EEG/fMRI to examine communication between the parietal and motor cortices, and between the hippocampus and parietal cortex during neural feedback learning, with the aim of developing strategies to optimise reach and hold movements driven by cortical stimulation (and subsequent cortical adaptation) of paraplegic patients. Furthermore, we plan to use fMRI, DTI and spectroscopy to examine processes underlying sensory information transfer, as well as to examine inflammation and neurodegeneration processes during the progression of multiple sclerosis (MS). DTI, fMRI, and resting state MRI (rsMRI) shall also be used to scrutinise the emotional and cognitive representations of pain, stress and personality, or affective, disorders, as well as putative changes in these putative biomarkers during therapy. The acquisition of a state-of-the art- 3,0 MRI device to replace our 12 year old current device will substantially strengthen our current research, and allow us to exploit the full potential of our acquired expertise in advanced MRI methodology. By this means we intend to make a novel contribution to our understanding of brain systems and neural subcompartments that support memory acquisition and updating, as well as cognitive processing in malaligned or disease states. By observing the brain during adaptive processes (neural feedback learning, cognitive adaptation to pain/stress/affective disorders, brain responses to therapeutic treatments) our hope is to use this methodology to expedite brain recovery, and/or resistance to pathological states.