Human-specific microglial receptor Siglec-11 in neuroinflammatory diseases

唾液酸结合免疫球蛋白样凝集素-11 （Siglec-11）和Siglec-16是最近发现的人类特异性cd33相关的Siglec，它们结合糖萼的唾液酸并在小胶质细胞上表达。在这个项目中，我们证明了小胶质细胞Siglec-11具有神经保护作用，依赖于神经元的唾液溶解糖萼。此外，我们建立了在小胶质ibal启动子下表达siglece -11的转基因小鼠。我们现在建议分析siglece -11在神经炎症动物模型中的作用，包括实验性自身免疫性脑细胞炎（EAE）和APP/ psi转基因小鼠。

Sialic-acid-binding immunoglobulin-like lectin-11 (Siglec-11) and Siglec-16 are recently identified human-specific CD33-related Siglec that bind to sialic acids ofthe glycocalyx and are expressed on microglia. In this project, we demonstrated that microglial Siglec-11 had neuroprotective effects dependent on the sialydated glycocalyx of neurons. Moreover, we established transgenic mice expressing Siglec-11 under the microglial Ibal-promoter. We now propose to analyze the role of Siglec-11 in neuroinflammatory animal models including experimental autoimmune encephalomyellfis (EAE) and APP/PSI-transgenic mice.