Magnetic Resonance without Magnetic Field

常规的高场液态核磁共振（NMR）是一种强大的方法，但实验需要在特定的环境中（在高度均匀的磁场内）进行，这阻碍了其在许多应用中的使用。通过溶解动态核极化（dDNP）[3-5]将零至超低场（ZULF）[1]的磁共振与超极化[2]耦合，允许在具有高磁化率异质性的金属容器和多孔介质等具有挑战性的环境中对任意分子进行灵敏的高分辨率磁共振。这需要一个强大的实验装置结合这两种技术。由于顺磁剂引起的弛豫，用dDNP在零场增强NMR是具有挑战性的。我们相信，通过使用法国共同申请人最近引入的超极化基质，将解除这种限制。我们将使用超极化和ZULF NMR的组合来研究不饱和化合物的催化氢化，非均相酶促过程以及低聚和聚合过程。特别地，这将使得能够通过NMR比较均相与非均相催化过程。

Conventional high field liquid state nuclear magnetic resonance (NMR) is a powerful method but experiments need to be performed in a specific environment (inside a highly homogeneous magnetic field), which prevents its use in many applications. Coupling magnetic resonance at zero- to ultralow field (ZULF) [1] with hyperpolarization [2] by dissolution-dynamic nuclear polarization (dDNP) [3–5] allows for sensitive high resolution magnetic resonance with arbitrary molecules in challenging environments like metal containers and porous media with high magnetic susceptibility heterogeneities. This requires a robust experimental setup combining the two techniques. Boosting NMR at zero field with dDNP is challenging because of relaxation induced by paramagnetic agents. We believe that this limitation will be lifted by the use of hyperpolarizing matrices recently introduced by the French co-applicant. We will use the combination of hyperpolarization and ZULF NMR to investigate catalytic hydrogenation of unsaturated compounds, heterogeneous enzymatic processes and oligomerization and polymerization processes. In particular, this will enable the comparison of homogeneous vs. heterogeneous catalytic processes by NMR.