Aerosol-assisted synthesis of spherical mesoporous CeO2 parTicles as smart nAnoCarriers for theranosTIC

如今，我们面临的问题是，传统的药物递送系统必须以高剂量系统地给药，并且由于健康组织/器官对药物的非特异性摄取而往往导致严重的副作用。在这项工作中，提出了一种易于控制的气溶胶为基础的方法，以生产生物相容性，介孔氧化铈颗粒具有良好的控制内部形态和壳孔隙率，用于控制药物的负载和释放性能。此外，为了有一个特定的释放，我们将化学修饰这些颗粒与改性多糖（刺激响应系统的阐述）。我们项目的最终目标是提出一个治疗诊断平台，能够评估病变细胞，并能够以可控的方式提供治疗分子。

Nowadays, we are faced with the issue that conventional drug delivery systems must be administered systematically in high doses and tend to cause severe side-effects because of the nonspecific uptake of drugs by healthy tissues/organs. In this work, an easily controllable aerosol-based approach is proposed to produce biocompatible, mesoporous cerium oxide particle with well-controlled internal morphology and shell porosity for controlling the drug loading and release properties. Moreover, in order to have a specific release we will chemically modify these particles with modified polysaccharides (elaboration of stimuli-responsive systems). The ultimate goal of our project is to propose a theranostic platform capable of assessing diseased cells and able to deliver therapeutic molecules in a controllable way.