Photoinduced regio- and enantio-selective C-N coupling of unactivated secondary alkyl halides

该项目旨在以区域和对映体选择性的方式合成化学和生物学上高度重要的氨基酸类型分子库。为了利用光和合适的配体构建这样的结构，需要开发新的合成方法。为此，铜催化的通常具有挑战性的仲碳卤素键的裂解将被区域选择性地进行，其中固有的有利的伯碳卤素和具有挑战性的仲碳卤素中心之间的区域选择性将被调整为有利于仲碳卤素中心，在Curtin-Hammett情景下或通过使用导向基团。为了对反应机理有一个非常详细的了解，需要进行计算。我们期望合成的化合物不仅可以用于生物学研究，而且可以作为催化领域潜在的配体库来开发新的转化。

The aim of this project is the synthesis of a library of chemically and biologically highly important amino-acid type molecules in a regio- and enantioselective fashion. Novel synthesis method(s) are to be developed in order to construct such structures using light and appropriate ligands. For this purpose, a copper-catalyzed cleavage of usually challenging secondary carbon-halogen bond is to be performed regioselectively, where the regioselectivity between the inherently favored primary carbon-halogen and the challenging secondary carbon-halogen center will be tuned to favor the secondary carbon-halogen center either under a Curtin-Hammett type scenario or by using a directing group. Computational calculations are to be performed in order to gain a very detailed insight into the reaction mechanism. We expect the synthesized compounds will not only be useful for biological studies, but will also serve as a potential ligand library in the field of catalysis to develop new transformations.