Development of statistical and computational methods, tools, and infrastructure as well as data analysis, data management, and support for clinical researchers

该子项目的主要目的是评估个体对新辅助治疗的反应，并揭示直肠癌患者对该治疗的不可耐受毒性反应。对于该评估，将根据受不同子项目影响的一组选定的不同生物标志物创建评分。通过分析治疗前采集的活检材料进行个体评估。为了获得评分相关数据，将使用定制微阵列分析基因表达。该阵列必须与我们的DNA微阵列设施（Transkriptomanalyselabor，TAL）合作设计，预处理和分析。监测和数据管理将与医学信息学部门合作进行。对于预期的项目，该临床研究单位将需要自2001年以来在哥廷根大学与几个医学能力网络（KND，AHF，CJK）合作开发的基本IT基础设施。临床研究部门将整合这些服务，从而可以使用可用的工具（例如，图像和生物材料库）。根据不同的研究项目进行定制后，它将作为操作基础设施。

The main objectives of this subproject are assessing individual response to neoadjuvant therapy and revealing non-tolerable toxic reaction to this therapy in patients with rectal cancer. For this appraisal, a score will be created based on a selected set of different biomarkers influenced by the different subprojects. The individual assessment is given by analyzing bioptic material, which is taken prior to therapy. To obtain the score-relevant data, gene expression will be analyzed using a custom microarray. This array has to be designed, preprocessed, and analyzed in collaboration with our DNA Microarray Facility (Transkriptomanalyselabor, TAL). Monitoring and data management will be performed in collaboration with the Department of Medical Informatics. For the intended projects, this Clinical Research Unit will need the basic IT-infrastructure that has been developed since 2001 at the University of Göttingen, in collaboration with several medical competence networks (KND, AHF, CJK). The Clinical Research Unit will incorporate these services, making it possible to use the available tools (e.g., image and biomaterial banks). After customizing to the different research projects, it will serve as operative infrastructure.