In vivo studies on the regulation of transcription and translation in Bacillus subtilis

由DNA组成的染色体的遗传信息被转化（转录）为RNA， RNA再被转化（翻译）为蛋白质。转录和翻译都是高度调控的过程，在细菌中被认为是非常紧密地一起发生的。最近的证据表明，这种紧密耦合并不像人们想象的那么广泛。该项目将继续研究参与不同类型RNA生产的转录复合物的组成，并研究活细胞中翻译偶联的水平。这将提供有关这些基本过程的有用信息。

Genetic information from a chromosome made of DNA is converted (transcription) into RNA that is then converted (translation) into protein. Transcription and translation are both highly regulated processes, and in bacteria are thought to occur very close together. Recent evidence suggests this close coupling is not as extensive as thought. This project will continue work to investigate the composition of transcription complexes involved in production of different types of RNA, and also to investigate the level of translational coupling in live cells. This will provide useful information on these fundamental processes.