Deciphering the role of protrudin regulating neuronal vesicular transport

我们研究了Protrudin调节神经元细胞内小泡运输的结构与功能的关系。Protrudin通过RBD11结构域与Rab11相互作用，通过FFAT基序与VAP和KIF5相互作用，通过非典型FYVE结构域与硫脂和PI(5)P相互作用。我们还创造了突起蛋白缺乏的小鼠，并发现突变小鼠的解剖和生理变化，表明突起蛋白有助于神经细胞的囊泡运输。

We investigated the structure-function relationship of protrudin that regulates intracellular vesicle transport in neurons. Protrudin interacts with Rab11 through the RBD11 domain, with VAP and KIF5 through the FFAT motif, and sulfatide and PI(5)P through the atypical FYVE domain. We also created mice deficient in protrudin and found that anatomical and physiological alterations in the mutant mice, suggesting that protrudin contributes to vesicular trafficking in neuronal cells