Viral RNA factory formation and activation of antiviral innate immunity

入侵的病毒RNA被细胞质中的rig - i样受体（RLR）感知，抗病毒先天免疫，包括干扰素的产生，被诱导。目前还不清楚RLR在哪里感知病毒RNA。我们发现病毒感染诱导rna -蛋白聚集，其中RLR被招募并作为病毒RNS感知的平台。我们将这种聚集体称为抗病毒应激颗粒（avSG）。我们还发现一些病毒积极抑制avSG以促进其复制。我们的发现还包括双链RNA传感器PKR和DHX36在avSG的形成中起关键作用。

Invading viral RNA is sensed by RIG-I-like receptor (RLR) in the cytoplasm and antiviral innate immunity, including production of interferon, is induced. It was unclear where RLR senses viral RNA. We found that viral infection induces RNA-protein aggregates, in which RLR is recruited and acts as a platform for viral RNS sensing. We termed this aggregate as antiviral stress granule (avSG). We also found that several viruses actively inhibit avSG to facilitate their replication. Our findings also include that the double-stranded RNA sensors, PKR and DHX36 play critical roles in the formation of avSG.