Establishment and development of stress biomarker of hard tissue

本人能够开展基于基因芯片的硬组织应激生物标记物发现研究，产生两个专利项目。为探索干细胞激活机制，作为干细胞应激生物标记物，成功提取A基因作为靶向。为了衡量A基因启动子的活性，从4000份左右的蔬菜提取物中筛选出100多个候选提取物。其中，当考虑到原料成本，并测试了几个可行的提取物，导致检查的有效性大于控制药物的效果只有今天的市场。作为皮肤应激的生物标志物，提取了衰老受体反应基因B。为了满足以及硬组织应激的生物标志物，类似于上面所述的作为指示基因B启动子活性的指标，目前正处于植物提取物的初步筛选阶段，约4000。最初的计划骨应激生物标志物的鉴定是重点，但它已经达到实用阶段，有望作为应激生物标志物在其他组织中应用。

I was able to perform the microarray-based stress biomarker discovery research of hard tissue, produce two patent projects.To explore the stem cell activation mechanism, as stem cell stress biomarker, successful extraction of gene A to be targeted. To index the promoter activity of gene A, were selected candidate extract more than 100 from vegetable extract of about 4000. Of these, when taking into account the raw material costs, and tested several as practicable extract, leading to check the validity of greater than control drug effect only on the market today. As a biomarker of skin stress, extracted the aging receptor response gene B. In order to meet as well as hard tissue stress biomarkers, similar to that described above as an indicator gene B promoter activity, it is in the beginning stages of screening plant extracts about 4000.The initial plan bone stress biomarker identification was focus, but it has reached the stage of practical use is expected as a stress biomarker in other tissues.