Nachwuchsakademie ‚Alterungsprozesse in der Reproduktion - Folgen für Fertilität und Gesundheit‘

生殖是一个高度复杂的协调细胞和内分泌过程的过程，超过了孩子的出生。除了男性和女性生育能力下降外，随着年龄的增长，性腺和生殖细胞特异性衰老过程也会导致遗传、表观遗传和内分泌变化。这些变化不仅是亚不育/不育的风险因素，也是后代健康和后代健康的风险因素。调节两性生殖衰老的分子机制仍然只得到部分理解，考虑到父母生育第一个孩子的年龄迅速增加，这是生殖医学研究中一个具有高度社会意义的科学挑战性课题。尽管出现了这样的研究问题，但德国从事生殖研究的大学院系数量正在减少。除了导致缺乏研究活动、可靠的知识获取和治疗选择外，德国还失去了与竞争激烈的国际研究水平的联系。因此，初级学院“生殖中的老龄化-对生育和健康的影响”旨在指导年轻的临床医生和科学家进行独立的研究项目。参与者将获得经验丰富的科学家（导师）的培训计划和支持，使他们能够提交精心设计的研究项目试点申请，并在成功完成这项工作后，通过完整的DFG应用程序继续科学工作。我们希望生殖过程中的衰老过程这一复杂的主题将伴随着出色的研究，并希望生殖研究作为一个整体将在德国得到可持续的促进。

Reproduction is a highly complex process of coordinated cellular and endocrine processes exceeding the birth of a child. In addition to a decrease in fertility in men and women, with increasing age also gonadand germ cell-specific aging processes lead to genetic, epigenetic and endocrine changes These not only represent a risk factor for sub-/infertility, but also for progeny health and those of the following generations. The molecular mechanisms that regulate reproductive aging in both sexes are still only partially understood and represent a scientifically challenging topic of research in reproductive medicine of high social relevance considering the rapidly increasing age of parents at birth of the first child. Despite such emerging research questions, the number of university departments for reproductive research in Germany is declining. Besides leading to a lack in research activities, reliable knowledge gain and therapeutic options, Germany also loses connection to the competitive international research level. The junior academy ‘Ageing in Reproduction- impact on fertility and health’ therefore intends to guide young clinicians and scientists towards independent research projects. Participants will receive a training program and support from experienced scientists (mentors) which allow them to submit well-designed pilot applications for research projects and after successful completion of this work the continuation of the scientific work by means of a full DFG-application. We hope that the complex topic of aging processes in reproduction will be accompanied by excellent research and that reproductive research as a whole will be sustainably promoted in Germany.