Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level

化学生物学是有机化学与分子生物学相结合的交叉学科。本研究融合了化学生物学和结构生物学的研究，构建了一个新的学术框架。我们开发了化学阵列系统，可以有效地检测生物活性小分子（配体）与其靶蛋白（受体）之间的相互作用，并快速分析构效关系。此外，配体与其受体之间的相互作用被成功地通过共晶体学证实。希望本研究能对药物的发现和生物科学的发展有所贡献。

Chemical biology is the interdisciplinary research area combining organic chemistry and molecular biology. In this study, we fused the research of both chemical biology and structural biology to construct a novel academic framework. We have developed chemical array system which can efficiently detect an interaction between bioactive small molecules (ligands) and their target proteins (receptors), and rapidly analyze the structure-activity relationship. Moreover, the interaction between a ligand and its receptor was successfully confirmed by co-crystallography. Our research outline is expected to contribute to drug discovery and progress of bioscience.