Multidimensional Electroseparation Systems for the analysis of complex bilogical samples

生物蛋白质组学和代谢组学样品的分析是困难的，因为组分的数量巨大且其丰度低。 二维电泳在灵敏度、动态范围和自动化程度等方面对质谱分析有很大的限制，而二维色谱系统效率低、耗时长。 本项目旨在通过开发多维电分离系统来开发新的蛋白质组分析技术，以提供高效、快速和灵敏的蛋白质组样品分析。

The analysis of biological proteomic and metaboleomic samples is difficult due to the enormous number of components and their low abundance. Two-dimensioal electrophoresis has many limitations with regard to sensitivty, dynamic range and automation to mass spectrometry, while chromatographic two-dimensional systems are inefficient and time consuming. This proposal aims at developing new technology for proteomic analyses by deveoping a multidimensional electroseparation system to provide highly efficient, rapid and sensitive analysis of proteomic samples.