Development and medical applications of water-soluble supramolecular polymer utilizing molecular techniques of Spiroborates

作为新材料开发的一部分，包括医用材料中使用的超分子聚合物，一种替代脂溶性超分子聚合物，已经被报道为“双碗”，研究了水溶性超分子聚合物，冠醚类螺硼酸盐阴离子宿主的制备，预计其比一般冠醚更坚固。我们制备了最后环化步骤的前体化合物，得到了像螺硼酸盐阴离子这样的冠醚。虽然没有得到目标的环螺硼酸盐阴离子，但从许多实验试验中，我们发现合适的模板分子阳离子共存在环化反应中是非常重要的。

As part of the new material development, including medical materials using supramolecular polymer, an alternative fat-soluble supramolecular polymer that already reported as "twinbowl", the research of preparation of water-soluble supramolecular polymer, crown ether-like spiroborate anions host, which is expected more robust than general crown ethers was perfomed. We prepared the precursor compound for the final cyclization step to give the crown ethers like spiroborate anion. Although the targeted cyclic spiroborate anion was not obtained, from many experimental trials, we found coexistence of suitable template molecule cations is very important in the cyclization reaction.