Cardiac effects of psychedelic drugs

一些致幻剂，如裸盖菇素、裸盖菇素、二甲基色胺和5-甲氧基二甲基色胺，正在被讨论作为治疗某些类型的抑郁症的药物。在这里，我们想知道这些致幻剂是否有心脏作用，以及它们是否通过5-HT4受体起到正性变力和正性变时性作用。为此，我们使用了一种转基因小鼠模型，该模型具有心脏特异性的人类5-HT4受体的过度表达，这是我们已经开发并表征的。此外，这些迷幻剂的心脏效应的信号转导应该被更详细地识别。该项目应有助于提高药物治疗的安全性，并改善对过量用药的治疗。

Some hallucinogens like psilocin, psilocybin, dimethyltryptamine, and 5-methoxy-dimethyltryptamine are under discussion as therapeutic drugs to treat some kinds of depression. Here, we want to know if these hallucinogens have any cardiac effects and if they act positive inotropic and positive chronotropic via serotonin 5-HT4 receptors. To that end, we use a transgenic mouse model with heart specific overexpression of human 5-HT4 receptors that has been developed and characterized by ourselves. Moreover, the signal transduction of the cardiac effects of these hallucinogens should be identified in more detail. The project should help to increase the safety of drug therapies and to improve the treatment of overdosage.