New mechanisms and methods in carbene and nitrene chemistry

卡宾和硝烯是有机化学中具有理论意义和机械意义的高活性中间体，具有合成的多功能性。尽管反应活性很高，但仍可以进行选择性和高产率的反应，从而产生其他方法难以或不可能合成的产品。它们在生物分子的光亲和标记和光刻方面有实际应用。这个项目将通过使用直接光谱观测来贡献对这些物种的性质和反应的基本知识。我们提出了新类型反应的发生和几个新的活性中间体的形成，以及一种通过将活性中间体并入大环框架来稳定活性中间体的技术。

Carbenes and nitrenes are highly reactive intermediates of theoretical and mechanistic significance and synthetic versatility in organic chemistry. In spite of high reactivity, selective and high-yielding reactions can be performed, leading to products that may be difficult or impossible to synthesise by other methods. They have practical applications in photo-affinity labelling of biomolecules, and photolithography. This project will contribute fundamental knowledge of the nature and reactions of these species by using direct spectroscopic observation. We are proposing the occurrence of novel types of reactions and the formation of several new reactive intermediates as well as a technique for the stabilization of reactive intermediates by incorporation into macrocyclic frameworks.