SFB 1665: Sexdiversity - Determinants, meanings and implications of sex diversity in sociocultural, medical and biological landscapes

性的分类以及性与性别之间的关系是我们对人体理解中最有争议的方面之一。最近，人文科学和生物科学都对纯粹的二元和本质化的性模型提出了实质性的批评。因此，新研究的出发点是观察到性是多层次的，动态的，需要依赖于上下文的参考框架。在本CRC中，我们的目标是在不同的研究背景下定义性别的多样性。在不同的分析层次中--从细胞到器官，从有机体到社会--并通过在每一个层次上描述性的决定因素、意义和含义，我们将具体说明“性”指的是什么。《儿童权利公约》将使我们能够解决一个核心假设，即性别是多样的，并通过在多个层面上出现的依赖于背景的差异来体现。我们将使用自然科学，人文科学和社会科学的前沿方法，以产生新的见解性别多样化的生物学，（生物）性别和（社会文化）性别规范对临床实践和生物医学研究的影响，以及性别类别的社会文化形成。CRC汇集了来自吕贝克大学的学者，研究人员和临床医生，他们在各自领域拥有丰富的专业知识，并且已经在性相关研究的基础，转化和临床方面进行了合作。他们得到了来自Christian-Albrechts-Universität zu基尔的专家的补充，与他们长期的科学和临床合作存在。他们还得到来自柏林、弗伦斯堡、马格德堡、慕尼黑和汉诺威的外部专家的补充，这些专家在人口与社会发展研究、性别研究和性别多样性的法律的方面具有专门知识。CRC的组织方式将促进生物科学、医学、人文科学和社会科学之间的跨学科工作。合作，我们将开发新的研究问题和性别多样性的理解，并在研究过程中涉及利益相关者和社会行为者，从而产生跨学科的影响。通过《儿童权利公约》，我们希望改变将性别视为生物医学研究和基础科学中的一个研究变量的方式，为性别提供定义和参考框架，这些定义和参考框架与其复杂性和多层次性相适应。这将导致对性别和性别多样性的更准确和更有区别的理解，从而为个性化医疗提供坚实的基础。人文和社会科学的贡献将是加深对性和性别的相互作用的理解，并支持方法的反思。CRC的研究结果将阐明性别和性别多样性的决定因素、意义和影响，这具有最大的社会相关性，也是我们作为人类自我概念的核心。

The categorisation of sex and the relationship between sex and gender are among the most controversial aspects of our understanding of the human body. Recently there has been substantial criticism by both the humanities and the biological sciences of an exclusively binary and essentialising model of sex. Thus, a starting point for new research is the observation that sex is multi-layered, dynamic, and in need of context-dependent reference frames. In this CRC, we aim to define the diversity of sex in different research contexts. In the different layers of analysis – from cells to organs, from organisms to societies – and by characterising the determinants, meanings and implications of sex at each of these levels, we will specify what “sex” refers to. The CRC will enable us to address the central hypothesis that sex is diverse and manifests itself through context-dependent differences that emerge on multiple levels. We will use cutting-edge methodology from the natural sciences, the humanities and social sciences to generate new insights into the biology of sex diversification, the impacts of (biological) sex and (socio-cultural) gender norms on clinical practice and biomedical research, and the sociocultural formation of sex categories. The CRC brings together scholars, researchers and clinicians from the Universität zu Lübeck with strong expertise in their respective fields, and who have already collaborated on fundamental, translational and clinical aspects of sex-related research. They are complemented by experts from the Christian-Albrechts-Universität zu Kiel, with whom long-standing scientific and clinical collaborations exist. They are further complemented by selected external experts from Berlin, Flensburg, Magdeburg, Munich and Hannover with specific expertise in DSD research, gender studies and the legal aspects of sex diversity. The CRC will be organised in a way that stimulates interdisciplinary work between biological sciences, medicine, humanities and social sciences. Collaboratively, we will develop new research questions and understandings of sex diversity, and involve stakeholders and societal actors in the research process, thereby generating transdisciplinary impact. With the CRC, we hope to change the way sex is considered as a research variable in biomedical research and basic science by providing definitions and reference frames for sex which are contextual and adequate for its complexity and multi-layered nature. This will lead to more accurate and differentiated understanding of sex and sex diversity and thereby provide a solid basis for personalised medicine. The contribution of the humanities and social sciences will be to deepen the understanding of the interaction of sex and gender, and support methodological reflexivity. The findings of the CRC will elucidate the determinants, meanings and implications of sex and sex diversity, which is of utmost societal relevance and at the very core of our self-concept as humans.