Targeting oxalate metabolism for renoprotection (B07 (C05))

草酸是一种代谢废物，在人体内没有已知的生理功能。作为饮食的一部分，它通过胃肠道被吸收，并被肾脏排除。尿草酸升高可能导致草酸钙晶体形成和慢性肾脏疾病(CKD)。拟议的项目旨在(1)确定肠道微生物组在草酸肾病中的作用并探索其肾脏保护潜力；(2)研究介导草酸诱导毒性的机制，重点关注草酸转运体SLC26A6的潜在肾脏保护作用；(3)确定与血浆草酸水平升高相关的发病率和死亡率，以及基因多态在慢性肾脏病患者中的作用。

Oxalate is a metabolic waste product without a known physiological function in humans. It is absorbed through the gastrointestinal tract as part of the diet and eliminated by the kidney. Elevated urinary oxalate may lead to calcium-oxalate crystal formation and chronic kidney disease (CKD). The proposed project aims to (1) define the role of the gut microbiome in oxalate nephropathy and explore its renoprotective potential; (2) examine the mechanisms mediating oxalate-induced toxicity with a focus on the potential renoprotective role of the oxalate transporter SLC26A6; (3) define the morbidity and mortality associated with increased plasma oxalate levels and the contribution of genetic polymorphisms in patients with CKD.