Correlation between semicircular ocular reflex and otolith ocular reflex and its application for clinical diagnosis using off-vertical axis rotation(OVAR)

前庭眼反射（VOR）在头部运动时产生代偿性眼球运动。VOR包括角VOR和线VOR。VOR处于自适应控制之下，该自适应控制在头部运动期间出现视觉前庭不匹配时校正VOR性能。大多数关于VOR可塑性的实验都使用了眼-眼反射（ScOR）。迄今为止，还没有关于耳石眼反射（OOR）的适应性可塑性对ScOR影响的研究。在本研究中，我们使用线性滑轨测试了ScOR因OOR的变化而改变的假设。为了修改OOR，我们使用了适应范式。8名受试者以0.125 Hz和60度/秒的峰值角加速度正弦旋转40分钟，同时佩戴双目放大镜（x 2范例）观察墙上的地球固定垂直条纹。四名受试者正弦旋转40分钟，同时观看头部固定的LED（x 0范例）。在x2范式中，8名受试者中有6名在适应后表现出OOR敏感性的增加。适应后OOR灵敏度增加的6名受试者中的每一名也在0.125 Hz下显示ScOR增益增加。在x 0范式中，4名受试者中有2名在适应后显示OOR敏感性降低。适应后OOR灵敏度降低的2例受试者中，每例受试者在0.125 Hz时ScOR增益也降低。这些结果表明，OOR和ScOR共享共同的神经通路，以这样的方式，一个通路的突触功效的变化是伴随着在其他相应的变化。

The vestibulo-ocular reflex(VOR) produces compensatory eye movements during head movements. The VOR consists of the angular VOR and the linear VOR. The VOR is under adaptive control that corrects VOR performance when visual-vestibular mismatch arises during head movements. Most experiments concerning plasticity of the VOR have used the semicircular-ocular reflex(ScOR). So far, there has been no investigation on the effect of adaptive plasticity of the otolith-ocular reflex(OOR) on the ScOR. In this study, using a linear sled, we tested the hypothesis that the ScOR is altered by changes in the OOR. To modify the OOR, we used an adaptation paradigm. Eight subjects were rotated sinusoidally at 0.125 Hz and 60 deg/sec peak angular acceleration for 40 minutes, while viewing earth-fixed vertical stripes on the wall while wearing the binocular magnifying lenses (x 2 paradigm). Four subjects were rotated sinusoidally for 40 minutes, while viewing head-fixed LED (x 0 paradigm). In the x 2 paradigm, 6 of the 8 subjects showed an increase in OOR sensitivity after adaptation. Each of the 6 subjects who showed an increase in OOR sensitivity after adaptation also showed an increased ScOR gain at 0.125Hz. In the x 0 paradigm, 2 of the 4 subjects showed a decrease in OOR sensitivity after adaptation. Each of the 2 subjects who showed an decrease in OOR sensitivity after adaptation also showed an decrease ScOR gain at 0.125Hz. These results suggest that the OOR and the ScOR share common neural pathways in such a way that a change in the synaptic efficacy of one pathway is accompanied by a commensurate change in the other.