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Plasticity in the vestibule-ocular reflex and its application for rehabilitation for the patients with peripheral vestibular disorders

前庭眼反射的可塑性及其在周围性前庭疾病康复中的应用

基本信息

批准号：
13671808
负责人：
KOIZUKA Izumi
金额：
$ 1.92万
依托单位：
St. Marianna University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

To elucidate the optical parameters in the training procedure for the patients with peripheral vestibular disorders, we investigated the usefulness of the sinusoidal off-vertical axis rotation (OVAR) to evaluate the otolith function in the healthy subjects (n=8), plasticity in the vestibule-ocular reflex (VOK) (n=9).In the sinusoidal nose-down OVAR, all subjects showed significant VOR gain reduction (p<0.05) in the OVAR at 0.8Hz compared with earth vertical axis relation (EVAR) at 0.8Hz. We concluded that the sinusoidal nose-down OVAR at 0.8Hz may evaluate the otolith function without discomfort for the patients with otolith disorders.In the plasticity experiments, 7 of the subjects who participated in the x2 adaptation experiment at 0.3 Hz and 30° amplitude showed a steady increase of VOR gain within a couple of trials. One of the remaining 2 subjects showed a decrease in VOR gain in all the three trials, and *ther subject showed a VOR gain increase in three trials and decrease in 2 trials. In the x2 adaptation experiment at 0.3 Hz and 80° amplitude (peak velocity : 28°/s), the percentage gain change ((post-pre)/pre) was 133% at the same stimulation and 100% at 0.4 Hz (peak velocity : 37°/s). The gain change was 65% at 0.1 Hz and 60° amplitude (peak velocity : 18%/s), and 64% at 0.2 Hz and 60° amplitude (peak velocity : 37° /s). In the xl adaptation experiment (30° at 0.3 Hz), the percentage gain change was -62% under the same conditions, 50% at 0.1 Hz and 60° amplitude, and -30% at 0.2 Hz and 60° amplitude. No change of VOR gain was observed at other frequencies, and the subject was not adapted at 0.1 Hz and 30° amplitude. The larger VOR gain increase in the x2 adaptation experiment for the faster head angular acceleration leads to the conclusion that the VOR gain mechanism can set very different gain states for the VOR that are quite similar in terms of the head acceleration.

为了阐明周围性前庭疾病患者训练过程中的光学参数，我们研究了正弦离垂直轴旋转（OVAR）评估健康受试者耳石功能（n=8）、前庭眼反射（VOK）可塑性（n=9）的有效性。在正弦鼻向下OVAR中，所有受试者在0.8Hz的OVAR中与0.8Hz的地球垂直轴关系（EVAR）相比，VOR增益显著降低（p<0.05）。在可塑性实验中，7名参与0.3Hz、30°振幅x2适应实验的受试者在几次实验中VOR增益稳定增加。其余2例受试者中的1例在所有3项试验中显示VOR增益降低，* 另1例受试者在3项试验中显示VOR增益升高，在2项试验中显示VOR增益降低。在0.3Hz和80°振幅（峰值速度：28°/s）的x2适应实验中，在相同刺激下的百分比增益变化（（后-前）/前）为133%，在0.4Hz（峰值速度：37°/s）下为100%。在0.1Hz和60°振幅下（峰值速度：18%/s），增益变化为65%;在0.2Hz和60°振幅下（峰值速度：37° /s），增益变化为64%。在xl适应实验（在0.3Hz下30°）中，在相同条件下，百分比增益变化为-62%，在0.1Hz和60°振幅下为50%，并且在0.2Hz和60°振幅下为-30%。在其他频率下未观察到VOR增益的变化，受试者在0.1 Hz和30°振幅下不适应。对于较快的头部角加速度，在x2适应实验中较大的VOR增益增加导致以下结论：VOR增益机制可以为VOR设置非常不同的增益状态，这些增益状态在头部加速度方面非常相似。