3T whole-body MRI with a high-performance research gradient system

本申请涉及最新一代磁共振成像仪（MRI）的采集。一方面，此次计划收购旨在通过提供新功能和软件界面，确保我们研究机构方法学开发工作的未来可持续性。另一方面，与该应用相关的技术增强-特别是更强和更可靠的磁场梯度-代表了成功的进一步研究和开发工作的基本先决条件，特别是对于肿瘤学研究领域正在进行和未来的项目（新型超极化造影剂的开发、扩散MRI、多参数成像、人工智能的应用）、神经科学这些应用包括脑功能成像（脑功能成像、高分辨率弥散加权微结构MRI）、肌肉骨骼和骨科应用（应力下的关节功能成像）以及心血管研究和应用项目（血管内介入、心脏功能MRI、4D血流）。计划工作的一个特殊技术方面是开发和优化微结构MRI的测量方法，特别关注测量参数的透明度和结果的可重复性，符合开放科学的趋势。收购计划的另一个方面是进一步发展我们的国际合作。我们近年来创建的MRI采集方法和图像重建环境（MREG/OVOC、Pulseq、前瞻性运动校正）现已安装在全球100多家外部合作机构。获得最新的硬件和软件平台对于我们为这些网站提供软件更新和长期支持，从而进一步支持和发展这些科学联系至关重要。

The present application refers to the acquisition of a magnetic resonance imager (MRI) of the latest generation. On the one hand, this planned acquisition aims to ensure the future sustainability of the methodological development work of our research institution by providing access to new functionality and software interfaces. On the other hand, the technical enhancements associated with this application - especially stronger and more reliable magnetic field gradients - represent an essential prerequisite for successful further research and development work, especially for the presented ongoing and future projects in the fields of oncological research (development of new hyperpolarized contrast agents, diffusion MRI, multiparametric imaging, application of artificial intelligence), neuroscience (functional brain imaging, high-resolution diffusion-weighted microstructure MRI), musculoskeletal and orthopedic applications (functional joint imaging under stress), as well as cardiovascular research and application projects (intravascular interventions, functional cardiac MRI, 4D flow). A particular technical aspect of the planned work is the development and optimization of measurement methods for microstructure MRI with a special focus on the transparency of measurement parameters and the reproducibility of results, in accordance with the open-science trends. Another aspect of the planned acquisition is the further development of our international cooperations. MRI acquisition methods and image reconstruction environments that we have created over the recent years (MREG/OVOC, Pulseq, prospective motion correction) are now installed at over 100 external cooperating sites worldwide. Access to the latest hardware and software platforms is essential for us for providing software updates and long-term support to these sites and thereby for supporting and developing these scientific contacts further.