Study on ionization of nonvolatile compounds and reactions of their ions in a gas phase.

1.在束电子轰击质谱的研究进展：（1）1.2-二酰基磷脂酰胆碱的在束电子轰击质谱不仅有MH^+峰，而且还有反映其结构的特征碎片峰。根据它们的相对丰度，鉴别位置异构体。(2)在束EI技术被证明是非常有用的表征核苷和单糖。(3)电子束EI和MIKES技术的结合被证明是非常强大的胆碱和季铵盐的裂解过程的解释.液相西姆斯质谱研究进展：（1）利用液相西姆斯次离子质谱与MS/MS联用技术，确定了盐生盐杆菌（Halobacterium halobium）脂质的主要成分为磷脂酰甘油磷酸甲酯。(2)用液相西姆斯/扫描联用技术分析了胆碱和乙酰胆碱卤化物的团簇离子，揭示了离子轰击诱导的化学反应。(3)测量了电荷转移复合物的西姆斯谱，证实了m-NBA基质中的氧化还原反应。

1. Developments in In-beam EI MassSpectrometry: (1) In-beam EI mass spectra of 1.2-diacylphosphatidylcholines exhibited not noly MH^+ but also diagnostic fragment peaks reflecting their sturctures. Based on their relative abundance the positional isomers were discriminated. (2) In-beam EI techique was demonstrated to be quite useful for characterization of nucleosides and monosaccharides. (3) A combination of In-beam EI and MIKES techniques was shown to be quite powerful for elucidation of fragmentation processes of choline and quaternary ammonium salts.2. Developments in Liquid SIMS Mass Spectrometry: (1) The major component of lipids of Halobacterium halobium was clarified to be a methyl ester of phosphatidylglycerophosphate on the basis of liquid SIMS spectra couples with MS/MS methods. (2) The ion bombardment induced chemical reactions in a matrix have been revealed in the cases of choline and acetylcholine halides on the basis of analysis of their cluster ions by use of liquid SIMS/linked scan techniques. (3) The SIMS spectra of charge-transfer complexes were measured and oxidation-reduction reactions in m-NBA matrix were demonstrated.