A probable xenogenization of mouse ascite tumor cells by mycoplasmas.

本文主要从抑制肿瘤细胞的角度，通过体外实验研究了埃利希小鼠腹水肿瘤细胞（AEC）与鸡败支原体的相互作用。实验结果如下：1。在5株鸡芽孢杆菌中，菌落HA和塑料表面粘附力较弱的菌株PG 31在体内表现出较弱的抑瘤作用，而其他4株菌株在体外均表现出较强的抑瘤作用。通过i-p或s-c接种的体内外试验，MR3菌株的活细胞悬液和细胞壁组分均能有效保护小鼠。这些材料的HA效价分别为1:128和1:16。相比之下，同一菌株的热灭活细胞和可溶性部分，HA滴度为1:4或更低，对小鼠没有保护作用。从这些和其他测试结果来看，支原体在体内粘附EAC的快速失活可能是由于肿瘤细胞的异种化。

Interactions between Ehrlich mouse ascite tumor cells (AEC) and Mycoplasma gallisepticum were investigated mainly from the standpoint of tumor cell supression by the in vitro-in vivo test. Results obtained are as followings:1. Among five M.gallisepticum strains tested, strain PG 31, which was weak in colonial HA and adherence to plastic surface, exhibited a weak tumor supression in vivo while the other four remarkably supressed the growth of EAC and showed strong reactions in the both in vitro tests.2. Both live cell suspension and cell wall fraction of strain MR3 effectively protected mice by the in vitro-in vivo tests performed by either i-p or s-c inoculation. The HA titers of these materials were 1:128 and 1:16, respectively. In contrast, heat inactivated cells and soluble fraction of the same strain, which exhibited HA titers of 1:4 or less, were ineffective in protecting mice.3. It was considered from these and additional test results that a rapid inactivation of EAC adhered by mycoplasmas in vivo may be due to the xenogenization of the tumor cells.