Development of the artificial bone for diagnosis

计算机断层扫描是一种无创性评估骨矿物质含量的方法。这种方法需要校准模体。在本研究中，校准骨模体是通过对制备的多核微囊或无机壁微囊(<I>和<lt；II&>型)进行模压成型(20t/&lt；cm^2&gt；)制成的。多核微胶囊为直径0.5~2.0 mm的明胶微球，内含多个二氧化钛微粒(金红石型，直径0.3微米)。将二氧化钛颗粒与尼龙12微球(直径为5.0微米)在自动陶瓷砂浆和搅拌器中室温共混60min，制得<i>型无机壁微胶囊。用冲击式杂交机制备了&lt；II&gt；型无机壁微胶囊。冲击压力使二氧化钛颗粒进入尼龙12微球表面，形成的微胶囊由无机化合物(壁材)和有机化合物(芯材)组成。通过改变两种化合物的混合比例，可以任意控制无机化合物和有机化合物的比例。本研究开发的材料使制备具有任意CT值的骨模型成为可能。所获得的骨模在X射线吸收方面非常均匀，似乎对评估骨矿物质含量非常有用。

Computed tomography is a method for noninvasive assessment of bone mineral content. This method needs calibration phantoms. In this study, the calibration bone phantoms were made by the compression molding(20 t/ <cm^2> ) of multicore microcapsules or inorganic wall microcapsules( <I> and <II> -types) prepared. The multicore microcapsules were gelatin spheres of 0.5-2.0 mm diameters containing many titanium dioxide particles(rutile type, diameter: 0.3 <micro> m). <I> -type inorganic wall microcapsules were prepared by blending the titanium dioxide particles and nylon 12 microspheres(diameter: 5.0 <micro> m) at room temperature for 60 min with an automatic ceramic mortar and stirrer. <II> -type inorganic wall microcapsules were prepared by an impact type hybridization machine. The impacting pressure drives the titanium dioxide particles into nylon 12 microsphere surfaces and the resulting microcapsules are made up of inorganic compound(wall material) and organic compound(core material). The ratio of the inorganic compound to the organic compound can be arbitrarily controlled by changing the mixing ratio of both compounds. The materials developed in this study make possible to prepare the bone phantoms having arbitrary CT-values. The bone phantoms obtained were extremely homogeneous in regard to X-ray absorption and seemed very useful for evaluation the bone mineral content.