The relationship between patterns of fetal breathing movements and the development of central nervous system

本研究通过实时超声b超对胎儿呼吸运动（FBM）的分析，探讨了评估人胎儿肺功能成熟的可能性。本文对15例正常孕妇进行了FBM各持续时间频率与孕龄的关系研究。从妊娠25 ~ 32周，连续FMB（持续时间为10秒）的频率显著降低。连续FBM持续时间为30秒的频率在同一年龄组显著增加。FBM持续10【g】30秒的频率与每小时胎心加速次数与长期胎力值密切相关。这些结果提示，胎儿连续FBM持续时间的延长与中枢神经系统的功能发育有关。根据72例最终早产的孕妇FBM的深度、不规则性和持续时间将其分为3种类型。随着FBM模式的成熟，新生儿呼吸障碍（包括RDS）的发生率显著降低。结果表明，FBM分析有助于胎儿肺功能成熟度的产前评估。

The possibility of the assessment of functional maturation of human fetal lung was investigated in this study through the analysis of fetal breathing movements (FBM) by real time ultrasonic B-scanner. The relationship between the frequencies of the various durations of FBM and the age of gestation was studied in 15 normal pregnant women. The frequency of successive FMB with a duration of 【ltoreg】10 sec. decreased sigificantly from 25 to 32 weeks of gestation. The frequency of succssive FBM lasted for 【gtoreg】30 sec. showd a significant increase at the same age. An intimate correlation was demonstrated between the the freqency of FBM lasted for 10 【gtoreg】30 sec., the number of fetal heart rate accelerations per hour and the value of long term valiavility. These results suggest that a prolongation of the duration of successive FBM fo the fetus is related to the functional development of the central nervus system.The pattern of FBM classified into 3 types by the depth, irregularity and the duration of FBM in 72 pregnant women who eventually underwent preterm deliveries. The incidence of neonatal respiratory disturbances including RDS decreased sigificantly with a maturation of FBM pattern. From these results showed that the analysis of FBM could contibute to the prenatal evaluation of the functional maturity of human fetal lung.