Role of Neuropilin-1 on Lung Macrophages during Pulmonary Inflammation

本项目将研究Nrp1配体在肺内单核细胞募集和巨噬细胞极化中的作用。在这个项目提案中，主要研究人员旨在为巨噬细胞上Nrp1的分子相互作用和信号伙伴提供新的见解，并表征骨髓单核细胞Nrp1在急性肺部炎症和消退的病理生物学中的作用。最终，这一结果将启动将这些发现转化为Nrp1抑制剂的开发，该抑制剂优先针对肺巨噬细胞，以获得治疗益处。

This project will investigate the role of Nrp1-ligands on monocyte recruitment and macrophage polarization in the lung. In this project proposal, the principal investigators aim to provide novel insight into the molecular interactions and signaling partners of Nrp1 on macrophages and to characterize the role of myelo-monocytic Nrp1 in the pathobiology of acute pulmonary inflammation and resolution. Ultimately, the results will initiate the translation of the findings into the development of an Nrp1 inhibitor which preferentially targets lung macrophages for therapeutic benefit.