Comparison of active source estimated by dipole tracing method and PET in human brain.

我们已经开发了一种计算机辅助的方法来估计的位置和矢量矩的发电机（例如电流偶极子）在人脑中。我们在波士顿马萨诸塞州总医院的临床神经生理学实验室使用我们开发并携带的偶极追踪（DT）系统对一名患者和六名正常志愿者进行了实验。异常脑电图定位：1例脑出血后出现高幅慢波脑电图，在过度通气下增强。利用DT系统估计了慢波的电位置。在DT研究之前，进行PET扫描以测量脑血流量和耗氧量。将DT估计的位置与PET图像和NMR图像进行比较。慢波的电定位估计在额叶皮质区的患侧和对应的正常脑组织显示的NMR和相对正常的血流显示的PET。2.采集正常人的视觉诱发电位，并利用DT系统进行分析。在一只眼的右视野、左半视野或全视野呈现棋盘格图案。DT分析的结果与人视网膜纹状体系统的解剖投影相吻合。

We have developed a computer-aided method to estimate the location and vector moment of an electric generator (e.g.a current dipole) in the human brain. Using the dipole-tracing (DT) system we developed and brought with us, we performed experiments on one patient and six normal volunteers at the Clinical Neurophysiology Laboratory of the Massachusetts General Hospital in Boston.1. localization of abnormal EEG: A patient showed a high amplitude slow wave EEG, which was augmented under hyperventilation, after cerebral hemmorrhage. The electric location of the slow wave was estimated using the DT system. Prior to the DT study, PET scanning was performed to measure the cerebral blood flow and oxygen consumption. The location estimated by the DT was compared with the PET images and NMR images. The electric location of the slow wave was estimated at the frontal cortical area of the affected side and corresponded with those of normal brain tissue revealed by NMR and relatively normal blood flow revealed by PET. But the reason why such a slow wave was generated in the patient still remained unsolved.2.Visual evoked potentials obtained from normal volunteers and analyzed by the DT system. A checker board pattern was presented at either reifht, left half or full field of one eye. The results obtained by the DT analysis corresponded well with the anatomical projection of the retinostriate system in human.