Relationship between body temperature and autonomic nervous tone in spontaneously hypertensive rat (SHR).
Relationship between body temperature and autonomic nervous tone in spontaneously hypertensive rat (SHR).
批准号:
62570075
负责人:
TSUCHIYA Katsuhiko
金额:
$1.15万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1987
资助国家:
日本
项目状态:
已结题
起止时间:
1987 至 1988
中文摘要
核心温度和自主神经音调与自发高密度比率(SHR,200 mmHg)、冲程前列SHR(SHRSP,250 mmHg)和京都Wistar大鼠(WKY,120- 130 mmHg)相比。(1)身体温度;每只老鼠都被放置在一个小的电线笼中,用于松弛的限制、温度(三)和尾部皮肤温度(TTail),并不断地记录下来。在60 - 90分钟的时间里,估计在受限制的开始时30分钟内进行。SHR、SHESP和WKY的平均值为38.70.3 ° C、38.30.3 C和37.70.1 C,相应地。在模型SHR>SHRSP>WKY,在模型SHR> SHRSP>SHR-WKYW的血液压力。2) Threshold core temperature; during a gradual rising of air temperature at constant rate of 0.2 C/min, stepwise increses in TTail were observed which indicate the tail vasodilation。SHR、SHRSP和WKY的尾部蒸发阈值核心温度分别为38.90.1 ° C、38.90.1 ° C和38.40.1 ° C。SHR的阈值核心温度高于其他两条直线中的阈值,而SHRSP的阈值低于SHR。(3)自主神经音调;用药理学方法估计的心脏自主神经音调(Lin和Horvath, 1972年)。在年龄6-7个月的雄性老鼠中,移情音调分别为19.4%、15.9%和15.2%,移情音调分别为38.3%、24.0%和29.6%。在这三条线之间,SHR都是对称性和偏对称性音调。(4)限制的影响; SHR、SHRSP和WKY (5- 7 M)的初始Tre分别为38.40.1 ° C、38.50.2 ° C和37.80.2 ° C。当老鼠被安置在受约束的笼子里, Tre和心脏的速率增加了,但最终却变得非常沮丧。在受约束的基础上,Tregegan到增加和减少的毕业生到初始水平。在限制开始后的10至30分钟内观察到的三重值的最大值。SHR中受限制的Tre的更高转变比其他人的更大,这些在年龄减少Tre的更高转变。
英文摘要
Core temperature and autonomic nervous tones were compared spontneously hypertensive rate (SHR,200 mmHg), stroke-prone SHR(SHRSP,250 mmHg) and Kyoto-Wistar rats (WKY,120-130mmHg). 1) Body temperature; Each rat was placed in a small wire-mesch cage for the loose restraint, rectal temperature(Tre) and tail skin temperature (Ttail) were recorded continuously. Tre was estimated in 30 min of 60th to 90th min from the beginning of the restraint. Mean Tre in SHR,SHESP and WKY of 6-9 Months old were 38.7 0.3゜C,38.3 0.3 c and 37.7 0.1 C,respectively. Tre were in the oder SHR>SHRSP>WKY,though blood pressure were in the oder SHRSP>SHR-WKYW. 2) Threshold core temperature; during a gradual rising of air temperature at constant rate of 0.2゜C/min, stepwise increses in Ttail were observed which indicate the tail vasodilation. Threshold core temperature for the tail vasodilation in SHR,SHRSP and WKY were 38.9 0.1゜C,38.9 0.1゜C and 38.4 0.1゜C,respectively. Threshold core temperature in SHR was higher than those in other two strains and it in the SHRSP was lower than SHR. 3) Autonomic nervous tone ; Cardiac autonomic nervous tones were estimated by the pharmacological method (Lin and Horvath, 1972). In male rats of 6-7 months old, parasympathetic tones were 19.4%,15.9 % and 15.2%, sympathetic tones were 38.3%,24.0% and 29.6%, respectively. Both sympathetic and parasympathetic tones in SHR were highest among the three strains. 4) Effect of the restraint; Initial Tre in SHR,SHRSP and WKY (5-7M) were 38.4 0.1゜C,38.5 0.2゜C and 37.8 0.2 c,respectively. When the rat was placed in the restrain cage, Tre and heart rate incresed but ttail sudtainly decreased. At the biginning of the restraint, Tre gegan to increase and declined gradually toword the initial level. Maximal values of the Tre were observed between 10th to 30th min after beginning of the restraint. An upper shift of Tre by the restraint in SHR was larger than those in others, and these upper shift of Tre decreased with age.
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Tsuchiya, K. et al.: "Threshold core temperatures for tail vasodilation during general warming in spontaneously hypertensive rat (SHR) and stroke-prone SHR (SHRSP)." Tropical Medicine. 30. 205-212 (1988)
Tsuchiya, K. 等人:“自发性高血压大鼠 (SHR) 和易中风 SHR (SHRSP) 总体变暖期间尾部血管舒张的阈值核心温度。”
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Tsuchiya, K. et al.: "Autonomic nervous tones in spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP)." Japanese Heart Journal. 28. 626 (1987)
Tsuchiya, K. 等人:“自发性高血压大鼠 (SHR) 和易发生中风的 SHR (SHRSP) 的自主神经张力。”
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Tsuchiya, K. et al.: "Change in body temperature with age in spontaneously hypertensive rat (SHR) and stroke-prone SHR (SHRSP)." Japanese Heart Journal. 29. 550 (1988)
Tsuchiya, K. 等人:“自发性高血压大鼠 (SHR) 和易发生中风的 SHR (SHRSP) 的体温随年龄的变化。”
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Tsuchiya, K. et al.: "Change of autonomic nervous tone in chronic spinal rats." International Journal of Biometeorology. 32. 223 (1988)
Tsuchiya, K. 等人:“慢性脊髓大鼠自主神经张力的变化。”
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Tsuchiya, K. et al.: Japanease Heart Journal. 28. 626 (1987)
Tsuchiya, K. 等人:日本心脏杂志。
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共 24 条
Relationship among blood pressure, tail blood flow and plasma catecholamine levels in chronic spinal rats.
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批准号:07670087
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:TSUCHIYA Katsuhiko
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依托单位: