Electron microscopic study of nonA, nonB hepatitis

本文观察了30例非甲非乙型肝炎患者肝细胞和枯否细胞的超微结构变化。在其中两个样品中发现了病毒样颗粒，一个直径约为11 nm，另一个直径约为8 nm。它们在枯否细胞胞质内呈晶体状排列。7例肝细胞核内可见核粒。在枯否细胞核内也有分布。2例库普弗细胞胞浆内可见管状网状结构。在慢性活动性肝炎患者肝细胞的rER中发现TRS样结构。TRS被报道为干扰素相关结构。通过我们的观察，提示了内源性干扰素的可能性，以阐明非甲非乙型肝炎肝毒性的未知机制。与包括儿科在内的其他部门的合作也很重要，因为我们遇到的患者为我们提供了丰富的非甲非乙型肝炎的形态学信息。

Ultrastructural changes of the hepatocyte and the kupffer cells in 30 patients with nonA, nonB hepatitis were examined. In two of them, virus-like particles were found. One was about 11 nm in diameter and the other was 8 nm. They were arranged like crystal in the cytoplasm of the Kupffer cell. Nuclear particles were found in the nucleus of the hepatocyte in 7 patients. They were also obaserved in the nucleus of the kupffer cell. In two cases, tubuloreticular structure (TRS) was found in the cytoplasm of the Kupffer cell. TRS-like structure was found in the rER of a hepatocyte in a patients with chronic active hepatitis. TRS is reported as interferon related structure. Through our observations, it was suggested that the possibility of intrinsic interferon was induced to elucidate the unknown mechanisms of hepatotoxicity in nonA, nonB hepatitis. Collaboration with other departments including pediatrics is also important to encounter with the patients who give us rich morphological information for nonA, nonB hepatitis.