Regulatory mechanism of atrial natriuretic peptide secretion and degradation ; especially in pathophysiological status

本研究的目的是，1)阐明心房利钠肽(ANP)在动物和人生理状态下的分泌和降解的调节机制；2)阐明充血性心脏病、肾脏疾病或血液透析等疾病对ANP分泌的影响；3)阐明血浆和尿液中ANP的分子形式在某些疾病中是否具有特异性；4)阐明从心房和脑分泌的ANP是否独立。结果，我们提出的所有问题都在所附论文标题中得到了完全或耐心的解决。最后，我们将逐步推进我们的研究，并探讨ANP与其他多肽的相关性，如内皮素或脑利钠肽。

Purposes of our study are, 1) to clarify regulatory mechanism of atrial natriuretic peptide (ANP) secretion and degradation in physiological status of animals and human, 2) to clarify effects of diseases such as congestive heart disease, renal diseases or hemodialysis on ANP secretion, 3) to clarify whether molecular forms of ANP in the plasma and urine have specificity in some diseases, 4) to clarify whether ANPs secreted from the atrium and the brain are independent or not.In results, all questions we proposed have completely or patially resolved in attached title of papers. Finally, we will advance our study progressively and investigate correlation between ANP and other peptides such as endothelin or brain natriuretic peptide.