Study on human parvovirus B19 infections

调查了日本人细小病毒B19相关的临床表现，因为除了感染性红斑外，没有做过任何检查。资料清楚地表明，该病毒可引起发热、不明原因的红斑性疾病、血管性紫癜、点状皮疹、多发性关节炎、溶血性贫血患者的再生障碍性危象、免疫抑制状态下的急性或持续性贫血以及胎儿疾病。1968年在感染性红斑患儿血清中检出人类细小病毒B19DNA，这可能是该病毒史上发现的最古老的病毒，绝对证实了感染性红斑的病因。早在1981年3月，日本大阪就发现了31例与该病毒有关的再生障碍性贫血危象。基础疾病为遗传性球形红细胞增多症30例和葡萄糖-6-磷酸脱氢酶缺乏症1例，这在世界上尚属首次。福冈、北九州、别府和大阪有6例非免疫性胎儿积水死亡病例是由B19感染引起的。在福冈市，15,000名活产婴儿中至少有3人在怀孕期间感染了这种病毒。确诊1例因病毒感染而流产。人类血浆衍生药物，一批凝血因子9复合体，

Clinical manifestations associated with human parvovirus B19 in Japan were investigated, because no examination had been done except erythema infectiosum.1. The data clearly showed that the virus caused febrile illness, unspecified exanthematous disease, vascular purpura, petechial rash, polyarthritis, aplastic crisis in patient with hemolytic anemias, acute or persistent anemia in patient under immunosuppressive state and fetal disorders.2. Human parvovirus B19 DNA was detected in sera of children with erythema infectiosum in 1968, which might be the oldest found in history of the virus, and absolute confirmation of the cause of erythema infectiosum.3. Thirty one cases of aplastic crisis were revealed in association with the virus in allover Japan, back to March 1981, Osaka. Underlying diseases were hereditary spherocytosis 30 and glucose-6-phosphate dehydrogenase deficiency 1, which was the first observation in the world.4. Six death cases of nonimmunologic hydrops fetalis were due to the B19 infection in Fukuoka, Kitakyushu, Beppu and Osaka. At least 3 of 15,000 live birth were killed with the virus during pregnancy in Fukuoka city. One abortion was confirmed due to the virus infection.5. Human plasma derived drug, one lot of the coagulation factor 9 complex,