A Study of the clinical application of the positron labeled compounds

近年来，f -脱氧葡萄糖（FDG）已被用作肿瘤寻找剂。^< 18b>的F-FDG在肿瘤中的蓄积理论比^<67>的Ga柠檬酸盐蓄积理论更容易理解，但对肿瘤诊断的敏感性并不好。为了增强肿瘤的可视化，采用因子分析法对肿瘤患者的动态影像进行分析。经^<18 b> F-FDG IV处理后，由配备专用高能正电子准直器的伽马照相机连续获得动态图像，并记录在计算机系统中。给药后60分钟拍摄全身图像。动态图像的因子分析能清晰地显示肿瘤的边缘，有助于提高肿瘤的诊断灵敏度。接下来，我们用一些大鼠研究了FDG在甲状腺的蓄积速率。静脉滴注^<18 b> F-FDG后，依次斩首处死大鼠，取甲状腺，称重，用井式闪烁计数器计数。正常大鼠60分钟F-FDG的积累比略高，与低碘饮食大鼠和TRH给药大鼠相似。最后研究了FDG对实验动物甲状腺癌的检测。将培养的人甲状腺癌移植给大鼠。我们研究了FDG在培养癌中的积累，部分采用放射自显影法，部分采用PET法，研究了FDG在培养癌中的积累。本研究结果发现，移植甲状腺癌中有^<14>的F-FDG和^<18>的F-FDG的肿瘤蓄积。这些结果提示，^<18 b>的F-FDG积累可能对癌症检测具有临床诊断价值。

Recently, ^<18>F-deoxyglucose(FDG) has been used as a tumor seeking agent. The theory of ^<18>F-FDG accumulation in tumor is more understandable than that of ^<67>Ga citrate, but the sensitivity of tumor diagnosis is not excellent. To enhance the tumor visualization, dynamic images were analyzed by the factor analysis in cancer patients. After IV administration of ^<18>F-FDG, dynamic images were obtained sequentially by gamma camera equipped with a special high energy collimator for positron and recorded in a computer system. Whole body images were taken at 60 minutes after administration. The factor analysis of the dynamic images shows the margin of the tumor clearly and contributes the sensitivity of tumor diagnosis.Next we studied the accumulation rate of FDG to the thyroid gland using some rats. After IV administration of ^<18>F-FDG, the rats were killed by decapitation sequentially and the thyroid gland were removed, weighed, and countered by the well-type scintillation counter. In normal rats, accumulation ratio of ^<18>F-FDG were slightly high at 60 minutes and similar to both low iodine diet rats and TRH administrated rats. Lastly we studied the detection of experimental animal thyroid cancer by FDG.The rats were transplanted the cultured human thyroid cancer. We studied the accumulation of FDG to the cultured cancer partly using ^<18>F-FDG by the autoradiography, and partly using ^<18>F-FDG by PET study. As the result of this study, we found the tumor accumulation of both ^<14>F-FDG and ^<18>F-FDG to the transplanted thyroid cancer. These results suggest that accumulation of ^<18>F-FDG may be of clinical diagnostic value for cancer detection.