Studies on Biologically Active Lignans from Medicinal Plants

1.二氧双环辛烷木脂素的单-和二-葡糖苷，松醇，梅迪普醇和阿宾加树脂醇，从杜仲皮和刺五加茎皮中分离得到，它们已被用作恢复性滋补品。讨论了苷元及其苷类化合物对环腺苷酸磷酸二酯酶抑制作用的构效关系。抑制作用大小依次为二葡萄糖苷配基>单葡萄糖苷。丁香树脂酚二-O-β-D-葡萄糖苷具有较强的抑制活性，对大鼠游泳运动有延长作用.结果表明，从水蜈蚣中分离得到的芝麻素具有明显的凝血活性。相关的木脂素类化合物d-芝麻素、松叶醇、异菊激肽、雨生芹素、牛蒡子苷元和matairesinol均未显示出活性.络石藤茎部分的水提取物，已被用于治疗血瘀（oketsu），显示出抑制活性的超氧化物的产生和松弛活性对组胺诱导的收缩气管肌肉在豚鼠。结果表明，这些活动取决于木脂素，牛蒡苷元，matairesinol，络石苷元和nortrachelogenin，这是可溶于醚馏分。葡萄糖苷类化合物未显示出活性。

1. Mono- and di-glucosides of dioxabicyclooctane lignans, pinoresinol, medioresinol and syringaresinol, were isolated from Eucommiae Cortex and Acanthopanax senticosus Stem Bark, which have been used as a restorative tonic. The structureinhibitory activity relationships of the aglycone and its glucosides on cyclic AMP phosphodiesterase inhibition were discussed. The order of inhibitory effect was diglucoside aglycone>monoglucoside. Syringaresinol di-O-beta-D-glucoside, which shows trong inhibitory activity, exhibited the prolonging effect on swimming exercise in rats.2. l-Sesamin isolated from Hydrocotgle sibthorpioides showed the blood coagulation activity. The related lignans, d-sesamin, pinoresinol, isohinokinin, pluviatolide, arctigenin and matairesinol, did not show the activity.3. Aqueous extract of stem part of Caulis Trachelospermi, which has been used for treatment of blood stagnant (oketsu), showed inhibitory activity of superoxide production and relaxant activity against histamine-induced contraction of tracheal muscles in guinea pig. It was shown that these activities depends on lignans, arctigenin, matairesinol, trachelogenin and nortrachelogenin, which are soluble in ether fraction. The glucosides did not show the activities.