Studies on the Synthesis of Physiological Active Terpenes and Development of New Synthetic Methods

1.生理活性萜类化合物的合成。(1)烯丙基硅烷基醛分子内环化合成Eudesman-α-亚甲基-6，12-内酯和-8，12-内酯。(2)甲酰化烯丙基卤化物分子内环化合成α-亚甲基-伽马-内酯中大环化合物的方法(3)生理活性环芳烃的合成：肉桂醇醋酸酯、9-烯-3-醇和脱氢松香醇。2.α-桑托宁和11-脱氢-α-桑托宁的微生物转化研究。(1)黑曲霉对三丁素的微生物羟基化作用。(2)黑曲霉对11-脱氢桑黄素的微生物羟基化反应。α，β-环氧亚砜作为有机合成中的有用中间体。(1)通过α，β-环氧亚砜进行碳同源反应合成α-取代的羰基化合物、α，β-不饱和酮和酯的新方法。(2)镁盐诱导α，β-环氧亚砜开放。α-氯酮、α-烷氧基酮的合成。(3)通过羟基开环合成α-酰基、3-酮和螺环醚的新方法。(4)以1-氯代烷基苯基亚砜和4-(苯硫基)丁醛为原料，通过α，β-环氧亚砜立体选择性合成(E_1-酰基丁二烯)。(5)α，β-环氧亚砜分子内自由基环化反应的新方法。(6)以α，β-环氧亚砜为原料合成醇类和经烯醇类化合物的新方法。4.光学活性对甲苯基亚磺酸作为手性助剂的不对称合成新方法。(1)手性环氧化物和烯丙醇的新合成。(2)1-氯-对甲苯基亚砜的合成工艺及不对称合成(+)-和(-)-反式亚砜的新方法。(3)(Z)-N-芳基氮杂环丙烷的新合成。

1.Synthesis of the Physiological Active Terpenes. (1)Synthesis of Eudesman-alpha-methylene-6,12-olide and -8,12-olide by Intra molecular Cycization of Allylic Silylated Aldehydes. (2)Synthetic Method of alpha-Methylene-gamma-lactones Fused to Medium and Large Membered Rings by Intramolecular Cyclization of Formylated Allylhalide (3)Synthesis of Physiological Active Eremophilanes: Cinalyratol Acetate, Aristol-9-en-3-ol and Debneyol.2.Studies on the Microbial Transformations of alpha-Santonin and 11-Dehydro- alpha-santonin. (1)Microbial Hydroxylation of Santonin by Asoeriaus niger. (2)Microbial Hydroxylation of 11- Dehydrosantonin by Asperigus niger.3. alpha,beta-Epoxy Sulfoxides as Useful Intermediates in Organic Synthesis. (1)A Novel Synthesis of alpha-Substituted Carbonyl Compounds, alpha,beta-Unsaturated Ketones, and Esters from Carbonyl Compounds with Carbon Homologation Through alpha,beta-Epoxy Sulfoxides. (2)Magnesium Salt Induced Opening of alpha,beta-Epoxy Sulfoxides. Synthesis of alpha-Chloroketones, alpha-Alkoxyketones. (3)A Novel Synthegis of alpha-Acyl-, 3-Keto-, and Spiro-Cyclic Ethers via Ring-opening alpha,beta-Epoxy Sulfoxides by Hydroxyl Group. (4)A Novel Steroselective Synthesis of (E 1-Acylbutadienes from 1-Chloro alkyl Phenyl Sulfoxides and 4-(Phenylthio)butanal Through alpha,beta-Epoxy Sulfoxides . (5)A Novel Method Annulation Through alpha,beta- Epoxy Sulfoxides with aid of Intramolecular Radical Cyclization. (6)A Novel Synthesis of Aldols and Through the Enolates from alpha,beta-EPOXY Sulfoxides.4.Novel Asymmetric Synthesis Using Optical Active p-Tolylsulfinyl Group as a Chiral Auxiliary. (1)A Novel Synthesis of Chiral Epoxides and Allylic Alcohols. (2)The Practical Procedure of 1-Chloro-p-tolylsulfoxides and a Novel As Asymmetric Synthesis of (+)-Disparule and (-)-trans-Disparule. (3)A Novel Synthesis of (Z)-N-Arylaziridines.