Studies on immunopathological, epidemiological analysis and control of schistosomiasis japonica in the endemic area around Tung-ting lake.

1988年开始在洞庭湖疫区开展日本血吸虫免疫病理、流行病学分析和防治的联合研究。1.三种血吸虫病疫源地的选择：(A)高发期疫区，(B)低流行期疫源地，(C)控制疫区。米洛市、满塘和临乡地区分别被选为(A)、(B)和(C)对应的试点地区。对上述疫源地的人、媒介钉螺流行现状进行了对比分析。2.对中国和日本相关的肝癌和肝硬变患者的免疫病理资料进行分析。并澄清了该病是否为原发性肝癌的原因尚无定论，但该病与肝硬变的密切关系显然是显著的。3.以病媒生物防治为目标，在血吸虫病流行区开展钉螺原虫检测工作。一种被发现的纤毛虫目前正在对其致病性进行检测。

Joint research on immunopathological, epidemiological analysis and control of schistosoma japonica in the endemic area around Tung-ting lake has been commenced in 1988. 1. The selection of three kinds of schistosomiasis foci such as (a) an area in high prevalent phase, (b) one in low prevalent phase and (c) one under controled phase for our researches. Milo-City, Mantang and Linxiang areas have been selected as pilot foci corresponding to (A), (B) and (C), respectively. Some comparative analysis of present epidemiological situations for humans and vector snails were made among above foci. 2. Immunopathological data of hepatic carcinoma and liver cirrhosis related to the disease were analyzed on the patients both in China and in Japan. And it was clarified that the question whether the disease is a cause of primary carcinoma of liver or not is still inconclusive but the close relation between the disease and liver cirrhosis is clearly significant. 3. Aiming at the biological control of vector sanils, the detection of protozoan parasites of snail was tried in the endemic area of schistosomiasis. A kind of ciliate found is now being examined on its pathogenesity.