REACTIVITY CONTROL IN ORGANIC CHEMISTRY

24位来自具有代表性的大学和研究机构的顶尖物理有机化学家组成了一个合作研究项目团队，其主要目的是试图从定量的角度对影响有机化合物活性的因素建立一个全面的了解。从1)结构变化的影响的传递：2)活性化学物种和同一性的化学：3)种间相互作用的检测和量化：4)涵盖分子聚集体和簇的主题的反应场的识别和表征的观点进行了探讨。项目组成员既包括对单个领域的研究，也包括对感兴趣的问题的连锁方面的讨论-合作。在最后研究报告的日文文本中引用了192篇各种方法的参考文献，从而说明了这一结果。具有代表性的结果是：a)阐明了有机阳离子物种和过渡态共有的电子需求程度；b)通过实验和理论方法阐明了分子缔合在Griganard反应、Wittig反应、S-NAR反应等亲核有机反应中的重要性。

Twenty four leading physical organic chemists in representative universities and research institutions made up a cooperative research project team.The major aim of the team is to try to establish a comprehensive understanding of the factors governing the reactivity of organic compounds in quantitative sense as far as possible. Approaches are made from the stand points of 1)transmission of the effects of the structural change: 2)chemistry of reactive chemical species and identities: 3)detection and quantilization of interspeclies interaction: 4)identification and characterization of the reaction field covering the topics of molecular aggregates and clusters.Members of the project team are involved both the research of the individual field and the discussion-cooperation of the interlocking aspects of the interesting problems. The results are exemplified by the 192 references in the varieties of the approach which are cited in the Japanese text of the final research report. Representative results are a)the elucidation of the degree of the electron demand common to organic cationic species and transition state; b)elucidation of the importance of the molecular association in the nucleophilic organic reactions such as Griganard Reaction, Wittig Reaction, S_NAr Reaction etc. through both experimental and theoretical approach.