Study on multi-phase artificial jaw and dental implant materials with soft-tissue affinity and biofunctionality

为了提高人工材料的软组织亲和性，使其与牙龈等周围组织紧密结合，我们尝试在材料表面包覆胶原蛋白。胶原固定化采用科研资助购置的等离子体聚合装置。首先，我们建立了适当的预处理和等离子体聚合的条件。通过该方法，胶原蛋白通过共价键与材料连接，并且即使在潮湿环境如活体中，也可以将胶原蛋白牢固且长期稳定地粘附在材料表面上。然后将胶原固定的多孔聚乙烯片植入大鼠背部皮下，观察其组织学反应。植入后不久，结缔组织长入多孔聚乙烯片的孔隙中，组织向内生长的速率显著提高 ...更多信息 D.周围组织将其自身附着到材料上，并且在材料-组织界面处观察到活体来源的胶原纤维牢固地附着到材料表面。这种情况在植入后持续了一年多。因此，该方法在提高人工材料的软组织亲和性方面是非常有效的，提示了该方法在临床上应用的可能性，同时，通过提供天然牙和骨组织所具有的生物功能，如畸形和抗冲击性，来提高牙种植体和人工颌骨的生物力学相容性。我们利用科研资助购买的有限元分析系统，分析了自然牙齿和骨骼在功能应力作用下的力学响应，结果表明，在静载荷下，牙周膜具有分散牙齿骨槽周围应力的作用，在动载荷下具有吸收冲击的作用。此外，这些结果表明，牙种植体应设计有一个减震结构的根内，它可以提供物理位移和吸震性像天然牙齿，以补偿牙周膜的功能。根据这些结果，我们开发了一种新的牙科种植体。结果表明，这种新型种植体具有更大的位移和更高的减震能力，因此，我们认为这种种植体在临床上是非常有效的。

In order to improve the soft-tissue affinity of artificial materials and to obtain a tight attachment of surrounding tissue such as gingiva, we tried to immobilize collagen onto the surface of materials. Collagen-immobilization was performed by a plasma-polymerizing apparatus, which had been purchased with grant-in-aid for scientific research. First, we set up the proper conditions for pretreatment and plasma polymerization. By means of this method, collagen wad connected with materials by covalent bonding, and it became possible to immobilize collagen firmly and with long-term stability onto the surface of materials even in a moist environment such as a living body. Then, collagenimmobilized porous polyethylene pieces were implanted subcutaneously in the backs of rats, and subsequent histological reactions were examined.As a result. connective tissue grew into the pores of the porous polyethylene pieces soon after implantation, and the rate of tissue ingrowth was substantially improve … More d. The surrounding tissue attached itself to the material, and at material-tissue interface living-body-originated collagen fibers were observed to be firmly attached to the surface of the material. This condition continued for more than one year after implantation. Therefore this method proved to be very effective in improving the soft-tissue affinity of artificial materials, suggesting possibility that this method could be clinically applied.At the same time, to improve biomechanical compatibility of dental implants and artificial jaw bones by providing biofunctionality such as deformity and shock-absorbablity such as that possessed by natural teeth and bony tissue. we analyzed the mechanical response of natural teeth and bones under functional stress using a finite element analysis system, which was purchased with grant-in-aid for scientific research.The result indicated that the periodontal membrane plays a role in dispersing stress around the bony sockets of teeth under a static load and absorbing shock under a dynamic load. Moreover, these results suggested that dental implants should be designed with a shock-absorbing structure inside the root, which could provide physical displacement and shock-absorbability like natural teeth in order to compensate for the function of the periodontal membrane. Following these results, we developed a new dental implant. which has a shock-absorbing structure inside the root, and we examined its actual displacement and shock-absorbability.Our findings indicated that the new dental implant had a larger displacement as well as a remarkably higher shock-absorbability Therefore, we expect that this implant will be very effective in clinical use Less