Studies on the sensory functions of the upper airway receptors, their central processing mechanisms and the contribution to the reflexes.

获得了以下结果。1.喉上神经(SLN)的整体神经活动和多个“驱动”和“压力”受体在正压作用下被刺激，而在上呼吸道负压作用下被抑制。2.喉内注射少量辣椒素可引起豚鼠呼吸暂停T_E明显延长。3.豚鼠喉部刺激性感受器几乎全部被蒸馏水刺激，但不能被生理盐水刺激。其中一些也可被等张葡萄糖刺激。4.机械刺激喉粘膜可引起豚鼠咳嗽反射。这种反射是由SLN和RLN传入共同调节的。5.室内空气对犬和豚鼠上呼吸道的气流刺激可引起明显的呼吸暂停。这种反射明显被温暖的空气抑制，而吸入薄荷脑则显著增强。6.明确了SLN的外支和逆行的喉神经含有传入纤维，其活动在上呼吸道阻塞时表现为呼吸调节。这些传入纤维也受到烟雾和水的刺激。上述结果将有助于了解喉传入信息及其反射，并对喉神经生理学的进一步研究具有重要意义。

The follwing results were obtained. 1. The whole nerve activity and a number of 'drive' and 'pressure' receptors of the superior laryngeal nerve(SLN) was stimulated by positive pressure and inhibited by negative pressure in the upper airway. in the guinea pig 2. A marked prolongation of T_E, apnea, could be elicited by application of a small amount of capsaicin into the larynx in the guinea pig. 3. Almost of laryngeal irritant receptors in the guinea pig were stimulated by distilled water but not by saline. Some of them could be also stimulated by isotonic dextrose. 4. Mechanical stimuli to the laryngeal mucosa evoked cough reflex in the guinea pig. Such reflex was mediated by both the SLN and RLN afferents. 5. Flow stimulus with room air into the upper airway in the puppy and guinea pig evoked a marked apnea. This reflex was clearly inhibited by warm air, whereas it was considerably augmented by inhalation of menthol. 6. It was clarified that the external branch of SLN and the reccurrent laryngeal nerve contain afferent fibers of which activity showed respiratory modulation during upper airway occlusion. These afferent fibers were also stimulated by smoke and water. These results mentioned above would be expected to contribute to understand the laryngeal afferent information and its reflex, and to further investigate the laryngoneurophysiology.