Synthetic Studies on the Integrated Control Function of the Masticatory System

研究结果总结如下：1)切断新生小鼠眶下神经，导致初级和次级神经元变性；2)切断Urotrichus和Suncus，导致咬合能力下降。3)HRP刺激三叉神经运动核后，网状结构内可见HRP标记的中间神经元。4)在豚鼠大脑皮质前、后咀嚼区到脑干中央模式发生器之间存在不同的神经元回路。5)证实了大脑对舌-下颌皮质运动的时间和模式进行综合控制的脑机制。6)将腭后粘膜上的机械应力传递到中央纹样发生器，并将纹样信息发送给合口运动和舌运动神经元，进行协同运动。7)去负荷大鼠，蛋白质和dna合成酶下降，供应…。锌摄入量增加，抗重力肌肉和内脏重量增加。8)味觉刺激和厌恶刺激引起的舌颌运动与腭部机械应力引起的舌下颌运动相对应。9)研制了具有下颌运动测量机构和学习能力的咀嚼机器人。10)脉冲电磁场诱导成骨样细胞[~(3 H)]TdR掺入依赖于cGMP依赖的蛋白激酶通路。11)骨细胞在破骨细胞活化和骨吸收调节中起重要作用。12)在3个大气压下连续加压，骨代谢为负值。13)硫杆菌属。从Calytogena sp.中分离到1个单株。(Mullusca)，生活在1100米的深海，并对其16S RNA序列进行了研究。优先地区科学研究补助基金的跨学科研究项目[咀嚼相关信息：其生物调控与发展](1992)起草并提交了计划。较少

Summary of the research results obtained is as follows : 1) The axotomy of the infraorbital nerve in newborn mice led to the degeneration of the primary and secondary neurons ; and 2) that of Urotrichus and Suncus caused the decline of biting ability. 3) HRP-labelled interneurons were observed in the reticular formation after the trigeminal motor nucleus exposed to HRP. 4) Different neuron circuits from the anterior and posterior masticatory area of the cortex to the central pattern generator in the brain stem were proved in guinea pig. 5) Brain mechanism by which the timing and pattern of the linguo-mandibular movements induced cortically are integratedly controlled was proved. 6) The mechanical stress on the posterior palatal mucosa was conveyed into the central pattern generator and the patterned information are sent to the jaw-closing motor and lingual motor neurons to conduct the co-operated movement. 7) In the load-discharged rats, the decline of protein and DNA synthsses, supply … More of Zn, and the weight of antigravity muscles and internal organs occurred. 8) Ingestive and aversive taste-stimulation-induced linguo-mandibular movements correspond to those induced by palatal mechanical stress. 9) The mastication robot bearing a jaw-movement measuring mechanism and learning ability was developed. 10) The incorporation of [ ^3H] TdR of the osteoblast like cells induced by the pulsed electromagnetic field is dependent on the cGMP-dependent protein kinase pathway. 11) The osteocytes play an important role in the activation of osteoclasts and the regulation of bone resorption. 12) The continuously-applied compressive pressure at 3 atmosphere led to negative bone metabolism. 13) The Thiobacillus sp. was singly separated from the Calyptogena sp. (Mullusca), living in 1, 100 m deep-sea, and the sequence of its 16S RNA was investigated.The program of the interdisciplinary research project [ Mastication-related information : its bio-regulation and development ], by Grant-In-Aid for Scientific Research on Priority Areas (1992) was drawn up to be submitted. Less