Influence of myeloperoxidase to angitis in Kawasaki disease.

我们检测了血清髓过氧化物酶（MOP）活性在各种类型炎症性疾病中的意义。方法和材料：这次我们检查了10种疾病；呼吸道感染、尿路感染、川崎病、淋巴腺炎、ITP、急性肾小球肾炎、过敏性紫癜、脓疱疮、急性阑尾炎、支气管哮喘。血清样本总数为87份。血清MPO活性测定方法采用Suzuki法。同时测定WBC、PMNs、CRP的数量。结果：血清MPO活性与各种疾病均无相关性，按CRP值分为7组，观察是否与MPO活性有关系。c反应蛋白阴性组与c反应蛋白阳性组之间经t检验p(0.0.1)，差异有统计学意义。中性粒细胞数量与MPO活性之间无相关性。从这个角度来看，我们得出结论，这种反应不是疾病本身的特征，而只是一种急性期反应物。至于川崎病，活性氧强烈影响引起血管炎的过程。定期测定6例川崎病患者的MOP活性。在发病初期，所有病例均表现为MPO活性升高。冠状动脉瘤的存在和不存在均不影响MPO活性。

We examined the significance of the serum myeloperoxidase (MOP) activity in the various type of inflammatory diseases.Method and material: This time we examined ten disease; RTI, UTI, Kawasaki disease, lymphoadenitis, ITP, acute glomerulonephritis, allergic purpura, impetigo, acute appendititis and broncheal asthma. Total number of serum sample was 87. As for the measurement method of serum MPO activity we followed that of Suzuki. At the same time number of WBC and PMNs, and CRP were measured.Result: In serum MPO activity and various diseases, there were no relationship each other They were divided into 7 groups by CRP value and examined if there was any relation ship with the MPO activity. Then significant difference was recognized by t-test to be p(00.1) between 2 groups: CRP negative groups and CRP positive groups. There were no relationship between the number of neutrophil and MPO activity. From this point of view, we concluded that this reaction is not characteristic to the diseases themselves, but just an acute phase reactant. As for Kawasaki disease, a reactive oxygen strongly influences aprocess of causing angitis. Then we regularly measured the MOP activity in 6 cases of Kawasaki disease. At the beginning of illness, all cases showed an increase of MPO activity. Both presence and absence of coronary aneurism did not influence MPO activity.