Development of a New Methodology for Pancreatic Diagnosis in Nuclear Medicine.

1.新的胰腺诊断用放射性药物的合成及其基础研究进行了胰腺显像剂的药物设计和合成，并考察了它们在胰腺诊断药物中的应用。(1)澄清了[S-甲基-C-11]-L-蛋氨酸作为胰腺诊断试剂用于正电子发射计算机断层扫描研究的一些问题。在PET定量分析中，C-11的最佳洗脱位置是蛋氨酸的羧基1。(2)葡萄糖是所有器官的重要能量来源。在此基础上，开发了一种新的与己糖激酶磷酸化反应相互作用的葡萄糖衍生物。(3)我们发现N-13-氨在人胰腺中迅速积累。在这项研究中，研究了胰腺对N-13-氨的摄取和代谢，并证明了其在胰腺成像中的作用。胰腺代谢功能定量分析方法的建立及其临床研究(1)胰腺癌与慢性胰腺炎的X线CT鉴别诊断一直比较困难。在这项研究中，只有胰腺恶性病变的F-18-2-氟-2-脱氧葡萄糖(FDG)摄取增加被认为有助于胰腺癌和慢性胰腺炎的鉴别诊断。(2)C-11-蛋氨酸被证明对胰腺功能的评估是有用的，尽管基础研究(1-(1))表明在胰腺中用C-11-蛋氨酸进行定量分析是困难的。(3)O-15-水的动态PET研究表明，在各种疾病中定量测量胰腺血流是一种有前途的方法。(4)HIPDM是一种脑灌注显像剂。本研究表明，I-123-HIPDM具有作为人胰腺显像剂的临床潜力。

1. Synthesis of new radiopharmaceuticals for pancreatic diagnosis and their basic researchDrug design and synthesis of some suitable compounds as pancreatic imaging agents were performed and their usefulness for pancreas diagnostic radiopharmaceuticals were investigated.(1) Some problems of [S-methyl-C-11]-L-methionine which has been used as a pancreas diagnostic agent for PET study were clarified. It was demonstrated that the best C-11 labeuing position was the carboxy1 group of the methionine for the quantitative analysis with PET.(2) Glucose is well known as an important energy source for all organs. On this basis, a new glucose derivative with an interaction to hexokinase phosphorylation reaction was developed.(3) We have found that N-13-ammonia rapidly accumulated in the human pancreas. In this study, the pancreatic uptake and metabolism of N-13-ammonia was investigated and its usefulness for pancreas imaging was demonstrated.2. Development of methods for the quantitative analysis of the pancreas metabolic functions and their clinical research(1) Differential diagnosis of pancreas cancer from chronic pancreatitis has been difficult with X-ray CT. In this study, only the malignant lesions of the pancreas showed increased uptake of F-18-2-fluoro-2-deoxy-glucose (FDG) was considered to be useful for differential diagnosis between pancreas cancer and chronic pancreatitis.(2) C-11-methionine was shown to be useful for assessment of the pancreas function though the difficulty of quantitative analysis using C-11-methionine in the pancreas was shown in the basic research (1-(1)).(3) It was demonstrated that the dynamic PET study with O-15-water is a promising method to measure pancreas blood flow quantitatively in various disease.(4) HIPDM was developed as a brain perfusion imaging agent. In this study, I-123-HIPDM was indicated to have clinical potential as a human pancreas imaging agent.