Chronobiological study on affective disorders using auto-regressive modelling. (Analysis of the relationship between HPA axis ans NA system)

本研究旨在研究躁狂抑郁障碍患者HPA轴和去甲肾上腺素能活动的时间生物学异常。比较了5例双相情感障碍患者和10例正常对照的血浆皮质醇、血浆游离和总MHPG以及核心体温的昼夜节律。患者组血浆皮质醇峰值提前，血浆游离MHPG水平降低。其中一名患者在不同的临床状态下进行了重复检查。结论：1.躁狂状态下总MHPG水平较高，抑郁状态下皮质醇高峰期较早。对5名双相情感障碍患者和4名对照进行纵向研究。在大约一年的时间里，每1-4周采集一次血样。测定血浆皮质醇、血浆游离MHPG和总MHPG，并用HRSD或Petterson躁狂评定量表评估临床状态。患者组血浆皮质醇水平较低。各患者皮质醇水平的变异系数均较大。1例快速循环症患者的Mani13EA-C评分与血浆游离MHPG.3水平显著相关。由于采用了自回归模型对数据进行分析，因此继续进行纵向研究。

The present study was designed to examine the chronobiological abnormalities of the HPA-axis and the noradrenergic activity in manic-depressive disorder.1. Circadian rhythms of plasma cortisol, plasma free and total MHPG, and core body temperature were compared in five bipolar patients and 10 normal controls. An earlier acrophase of plasma cortisol and a lower level of plasma free MHPG were observed13EA\ : in the patient group. One of the patients was examined repeatedly in different clinical states. The level of total MHPG was higher in a manic state and the acrophase of cortisol earlier in a depressive state.2. Five bipolar patients and four controls were studied longitudianally. Blood samples were obtained every 1-4 week for about a year. Plasma cortisol, plasma free and total MHPG were measured and the clinical state was estimated using the HRSD or th13EA\ : e manic rating scale of Petterson. In the patient group the level of plasma cortisol was lower. The coefficient of variation of cortisol level of each patient was higher. A patient with rapid-cycling showed a significant correlation between the mani13EA\ : c rating score and the plasma level of free MHPG.3. Longitudinal study has been continued because of the application of autoregressive modelling for the analysis of the data.