Cloning of Glicma Specific Tumor Supressor Gene

对9例恶性胶质瘤(7例胶质母细胞瘤和2例恶性星形细胞瘤)的11例肿瘤组织进行了10号染色体基因缺失检测。在7例胶质母细胞瘤中有4例(57%)发现结构杂合性丢失，而在2例恶性星形细胞瘤中保留了杂合性。1例胶质母细胞瘤仅在复发的肿瘤组织中表现为结构杂合性丢失，虽然在最初的肿瘤组织中保持杂合性，但讨论了杂合性丢失在胶质母细胞瘤生长和复发中的意义。

Gene deletion of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma ( seven glioblastomas and two malignant astrocytomas ) was investigated. Loss of constitutional heterozygosity was found in four of the seven ( 57% ) cases with glioblastoma, whereas heterozygosity was preserved in two malignant astrocytoma cases. One glioblastoma case showed loss of constitutional heterozygosity only in the recurring tumor tissue, although heterozygosity was maintained in the initial tumor tissue The significance of loss of heterozygosity in the growth and recurrence of glioblastoma is discussed.