Role of phospholipid hydroperoxide glutathione peroxidase (PHGPx) in sperm maturation

将在人类和实验动物中研究精子中PHGPx含量与雄性生育力之间的关系。将通过分析化学和分子生物学技术研究精子细胞中的可溶性过氧化物酶PHGPx转化为成熟精子中的无酶活性结构蛋白的过程。特别感兴趣的是/i）促进PHGPx转化的催化剂和/或共反应物，ii）所需氧化剂的来源和性质，和/iii）该分化过程的触发机制。

The relationship between PHGPx content of sperm and male fertility is to be investigated in humans and experimental animals. The process leading to a transformation of the soluble peroxidase PHGPx in spermatids to an enzymatically inactive structural protein in mature spermatozoa is to be investigated by analytical chemistry and molecular biology techniques. Of particular interest are/i) the catalysts and/or co-reactants contributing to the transformation of PHGPx,ii) the source and nature of the oxidants required, and/iii) the triggering mechanisms underlying this differentiation process.